Asokarishta possesses significant analgesic activity. Adhatoda vasica, Nigella sativa and Asokaristapotentiated the pentobarbital sleeping time, where as Pterocarpus santalinus antagonized thesleeping time. Excluding Adhatoda vasica and Nigella sativa rest of them decreased the spontaneousmotor activity of the animals. Asokarista exhibited the most powerful antagonist of theamphetamine-induced hyperactivity followed by Saraca asoca and Nymphaea lotus. But Nigellasativa is the only component to increase the amphetamine-induced hyperactivity. The asokarista,Nymphaea lotus and Adhatoda vasica showed significant depressant effect on hole cross test.Asokarista, Adhatoda vasica, Nigella sativa, Nymphaea lotus and Saraca asoca also showed reducedmovements in open field experiment. The asokarista and its major components exhibiteddepressant effect on ambulation and head dipping on hole-board test. Climbing out experimentalso support the previous findings.