Effect of Rhizoma Gastrodiae on cultured mouse spinal motor neuronsdamaged by xanthine oxidase and hypoxanthine > Volume 01 - 2001

본문 바로가기

사이트 내 전체검색


 » New Articles(2011~Present)
 » Articles (2001~2010)
      ∙ Volume 10 - 2010
      ∙ Volume 09 - 2009
      ∙ Volume 08 - 2008
      ∙ Volume 07 - 2007
      ∙ Volume 06 - 2006
      ∙ Volume 05 - 2005
      ∙ Volume 04 - 2004
      ∙ Volume 03 - 2003
      ∙ Volume 02 - 2002
      ∙ Volume 01 - 2001
 

Oriental Pharmacy and Experimental Medicine
Volume 01 - 2001
Date: 2001

Journal: Pages 75-78

August 2001 | Effect of Rhizoma Gastrodiae on cultured mouse spinal motor neuronsdamaged by xanthine oxidase and hypoxanthine…

Seung-Taeck Park1, Se-Jin Jeong1, Jung- Gu Cho1, Kang-Chang Lee1, Hyang-Suk Yoon1, Gi-YeunHong1, Bu-Gi Min1, Seung-Ho Chun2, Gap-Sang Lee2, Kang-Kyung Seong3, Geon-Mok Lee3 andJae Han Shim4

첨부파일

Summary

​To evaluate the cytotoxic effect of oxygen radicals, xanthine oxidase(XO)/hypoxanthine(HX)-induced neurotoxicity was examined in cultured newborn mouse spinal motor neurons afterspinal motor neurons were grown in the media containing various concentrations of XO/HX.And also, the protective effect of Rhizoma gastrodiae (RG) extract against XO/HX-inducedneurotoxicity was evaluated. Cytotoxicity was measured as a cell viability adopted by 3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyltetrazolium bromide (MTT) assay. In this study, exposure ofmotor neurons to XO/HX induced cell death significantly, in a dose- and time-dependentmanners in spinal motor neuron cultures. The decrease in cell viability of motor neuronsdamaged by XO/HX was proventioned by RG extract. These results suggest that theneuroprotective effect of RG extract on XO/HX-induced neurotoxicity may result from aattenuation of oxygen radicals.


This website Copyright (c) 2014 Institute of Korean Medicine Kyung Hee University All rights reserved.
Top View
Mobile View