Central nervous system depressant effect of hot water extract of Ocimumsanctum Linn. (Labiateae) > Volume 02 - 2002

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Oriental Pharmacy and Experimental Medicine
Volume 02 - 2002
Date: 2002

Journal: Pages 101-105

August 2002 | Central nervous system depressant effect of hot water extract of Ocimumsanctum Linn. (Labiateae)…

Mahiuddin Alamgir1,*, Md. Shahabuddin Kabir Choudhuri2, Shaila Jabbar3, Sultana Rajia2 andMahmud Tareq Hassan Khan3

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Summary

​A battery of neuropharmacological experiments showed the hot water extract of Ocimum sanctumLinn. (Labiateae) had a depressant effect on the central nervous system (CNS), but the aqueousextract showed no effect on it. The hot water extract reduced the spontaneous locomotor activity,exploratory head dipping, propulsive locomotion and exploratory ambulation as well as prolongedthe pentobarbital induced sleeping time. The depressant effect starts from 60 minutes after thedrug administration and continued to 180 minutes. The drug may exert central depressant effectby interfering with the function of the cortex.


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