Magnoliae Cortex inhibits immediate-type allergic reactions > Volume 02 - 2002

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Oriental Pharmacy and Experimental Medicine
Volume 02 - 2002
Date: 2002

Journal: Pages 106-112

August 2002 | Magnoliae Cortex inhibits immediate-type allergic reactions…

Tae-Yong Shin1, *, Ro-Sa Oh2, and Eon-Jeong Lee2

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Summary

​The effect of aqueous extract of Magnoliae Cortex (Magnoliaceae) (MCAE) on the immediate-typeallergic reaction was investigated. MCAE inhibited compound 48/80 induced systemic anaphylacticreaction in rats. MCAE (0.1 and 1 g/kg) also significantly inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylactic (PCA) reaction. MCAE (0.001 to 1 mg/ml) dose-dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated bycompound 48/80 or anti-dinitrophenyl (DNP) IgE. Moreover, MCAE (0.01 to 1 mg/ml) had asignificant inhibitory effect on anti-DNP IgE-mediated tumor necrosis factor-a (TNF-a) production.These results indicate that MCAE inhibits immediate-type allergic reaction in vivo and in vitro.


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