In our study, the several cytokines were determined in phytohaemagglutinin (PHA)-stimulatedperipheral blood mononuclear cells (PBMC) of Adamantiades-Behçets patients. Adamantiades-Behçets disease (ABD) is a systemic inflammatory disorder and might involve immune dysfunction. Highlevels of TNF-a, IL-1b and IFN-g indicate the activation of inflammatory reactions and immunesystem in ABD. Gami-Phedoc-San (GPS) is an Oriental herbal medication, which has been used inKorea for the treatment of ABD. GPS (1mg/ml) significantly inhibited the secretion of proinflammatorycytokines, TNF-a and IL-1b, compared to absence of GPS (by 50.5±1.9% inhibition for TNF-a and106.9±16.8% for IL-1b). GPS also inhibited the production of IFN-g, immunoregulatory Th1cytokine, by 78.4±2.8%. The inhibitory effects of GPS on cytokine secretion showed dose-dependentmanner, and the pre-treatment of 1 mg/ml GPS had better effects than immunosuppressive drugfor treatment of ABD, cyclosporin A. Our results suggest that GPS treatment for ABD patientsmight have pharmacological activity of immune and inflammatory responses through thecytokine modulation.