The inhibitory effects of Gami-Phedoc-San on TNF-aaaa, IL-1bbbb and IFN-gggg secretionfrom human monocytes > Volume 02 - 2002

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Oriental Pharmacy and Experimental Medicine
Volume 02 - 2002
Date: 2002

Journal: Pages 41-46

Fbruary 2002 | The inhibitory effects of Gami-Phedoc-San on TNF-aaaa, IL-1bbbb and IFN-gggg secretionfrom human monocytes…

Mi-Sun Kim1, Eun-Hee Lee1 and Se-Young Choung2, *

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Summary

​In our study, the several cytokines were determined in phytohaemagglutinin (PHA)-stimulatedperipheral blood mononuclear cells (PBMC) of Adamantiades-Behçets patients. Adamantiades-Behçets disease (ABD) is a systemic inflammatory disorder and might involve immune dysfunction. Highlevels of TNF-a, IL-1b and IFN-g indicate the activation of inflammatory reactions and immunesystem in ABD. Gami-Phedoc-San (GPS) is an Oriental herbal medication, which has been used inKorea for the treatment of ABD. GPS (1mg/ml) significantly inhibited the secretion of proinflammatorycytokines, TNF-a and IL-1b, compared to absence of GPS (by 50.5±1.9% inhibition for TNF-a and106.9±16.8% for IL-1b). GPS also inhibited the production of IFN-g, immunoregulatory Th1cytokine, by 78.4±2.8%. The inhibitory effects of GPS on cytokine secretion showed dose-dependentmanner, and the pre-treatment of 1 mg/ml GPS had better effects than immunosuppressive drugfor treatment of ABD, cyclosporin A. Our results suggest that GPS treatment for ABD patientsmight have pharmacological activity of immune and inflammatory responses through thecytokine modulation.


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