Inhibitory effect of Se-Yeon-Eum on nicotine- and cigarette smoke extract-induced cytotoxicity in human lung fibroblast > Volume 02 - 2002

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Oriental Pharmacy and Experimental Medicine
Volume 02 - 2002
Date: 2002

Journal: Pages 47-51

Fbruary 2002 | Inhibitory effect of Se-Yeon-Eum on nicotine- and cigarette smoke extract-induced cytotoxicity in human lung fibroblast…

Chong-Shik Jin1, Mi-Sun Kim1, Eun-Hee Lee1, Joon-Ho Lee1, Jong-Hyun Lee1, Su-Jin Moon1, Bo-RaLee1, Kyung-Phil Jung1 and Hong Yuan Li2, *

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Summary

​There are over 4,000 different chemicals in cigarette smoke, including nicotine and tar. Thesecompounds influence on lung tissue directly or indirectly. In this study, we have examinedwhether an aqueous extract of Se-Yeon-Eum (SYE), composed of Oriental medicine that has beenknown to be effective to symptom by smoking, inhibits nicotine- or cigarette smoke extract (CSE)-induced cytotoxicity in human embryonic lung fibroblast, MRC-9. Assessment of cell viabilityusing 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay indicatedthat SYE inhibited not only nicotine-induced cytotoxicity but also CSE-induced cytotoxicity.These results suggest the possibility that the use of SYE may be useful for improvement of manysymptoms by smoking.


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