Antitumor evaluation and antimicrobial activity of geranyl phenyl ethers > Volume 02 - 2002

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Oriental Pharmacy and Experimental Medicine
Volume 02 - 2002
Date: 2002

Journal: Pages 52-57

Fbruary 2002 | Antitumor evaluation and antimicrobial activity of geranyl phenyl ethers…

Hyun-Ju Oh,1 Ji-Hee Shin,1 Woo-Young Chung,2 Du-Seok Han2 and Seung-Hwa Baek1,*

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Summary

​Geranyl phenyl ethers 1, 2, 3, 4 and 5, 5-fluorouracil 6 and adriamycin 7 as references were testedfor their growth inhibitory effects against tumor cell lines and NIH 3T3 fibroblasts using twodifferent assays, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) andsulforhodamine B protein (SRB) assays. These results suggest that methyl-4-[{(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-methoxy benzoate 1 showed growth inhibition activity against tumor celllines. The maximum activity exhibited by methyl-4-[{(2E)-3,7-dimethyl-2,6-octadienyl}oxy]-3-hydroxybenzoate 3 against Staphylococcus epidermidis (MIC, 1,000 mg/ml).


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