Effect of Rubus coreanus Miq. fruit extract on compound 48/80-inducedanaphylactic reactions > Volume 02 - 2002

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Oriental Pharmacy and Experimental Medicine
Volume 02 - 2002
Date: 2002

Journal: Pages 58-63

Fbruary 2002 | Effect of Rubus coreanus Miq. fruit extract on compound 48/80-inducedanaphylactic reactions…

Suk-Hyun Kim1, Kyung-Bo Lee1, Yong-Gil Choi1, Jae-Kwan Lee1, Sung-Hwa Kim1, Sang-Hyun Kim2and Tae-Yong Shin1,*

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Summary

​The effect of the aqueous extract of Rubus coreanus Miq. (Rosaceae) fruits (AERC) on anaphylacticreaction was investigated. AERC completely inhibited compound 48/80-induced systemic anaphylacticshock at dose of 0.1 to 1.0g/kg. When AERC was pretreated at concentrations ranging from 0.01to 1.0g/kg, the plasma histamine levels induced by compound 48/80 were reduced in a dose-dependent manner. AERC also inhibited the histamine release from rat peritoneal mast cells(RPMC) by compound 48/80. The level of cAMP in RPMC, when AERC (1.0mg/ml) was added,transiently and significantly increased about 6-fold compared with that of basal cells. These resultsindicate that AERC may be beneficial in the treatment of non-specific anaphylactic reactions.


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