Screening the extracts of the seeds of Achillea millefolium, Angelica sylvestrisand Phleum pratense for antibacterial, antioxidant activities and generaltoxicity > Volume 03 - 2003

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Oriental Pharmacy and Experimental Medicine
Volume 03 - 2003
Date: 2003

Journal: Pages 157-162

September 2003 | Screening the extracts of the seeds of Achillea millefolium, Angelica sylvestrisand Phleum pratense for antibacterial, antioxidant activities and generaltoxicity…

Satyajit Dey Sarker1,*, Elaine Eynon1, Katharine Fok1, Yashodharan Kumarasamy1, Eaván MarieMurphy1, Lutfun Nahar2, Ehab Mohammed Shaeen1, Nichola Mary Shaw1 and Munachonga Siakalima1

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Summary

​Various extracts of higher plants have been used in traditional medicine systems for centuries.While tropical and sub-tropical plants have received considerable attention from the researchersfor evaluation of their bioactivity, temeperate plants have always been neglected somewhat.Similarly, seeds of the plants have not been considered seriously compared to other plant parts,e.g. leaves, stems, roots, flowers, etc. as a potential source for biologically active compounds. Aspart of our on-going evaluation of the extracts of the seeds of temperate plants, especially fromScotland, for biological activity, Achillea millefolium, Angelica sylvestris and Phleum pratense havebeen chosen for the present study. Both A. millefolium and A. sylvestris are well known for theirtraditional medicinal uses in Europe and also in the orient, but there is no report on any medicinalproperties of P. pratense available to date. Extracts of the seeds of these plants have been assessedfor their antioxidant and antibacterial potential and also for general toxicity. Both DCM andMeOH extracts of A. millefolium showed the most significant broad spectrum antibacterial activityamong the three plants and inhibited the growth of almost all test strains of bacteria. The DCMextracts of all three species were active against methicillin resistant Staphylococcus aureus (MRSA)and Citrobacter freundii (MIC=6.25×10-1 mg/mL). While the MeOH extracts of A. millefolium and P.pratense were active against C. freundii, that of P. pratense was also active against MRSA. TheMeOH extract of A. sylvestris did not show any antibacterial activity against any of the eightbacterial strains at test concentrations. The MeOH extract of P. pratense showed the mostprominent antioxidant activity (IC50=145 mg/mL) and there was no antioxidant activity observedwith the DCM extract of A. millefolium. The DCM extract of P. pratense was the most toxic (LC50=20mg/mL) among the extracts.


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