Water extract (kwath) of six different widely used Ayurvedic medicinal plants were tested inmice for possible neuropharmacological efficacy. In the present experiments it was observed thata number of plant tested causes a significant level of Central Nervous System (CNS) depression,in that it significantly decreased the spontaneous Motor activity, and also lowered the exploratorybehavior of the treated animals. Terminalia chebula (HAA), Terminalia bellerica (BHA), Emblicaofficinalis (AA), Piper longum L. (PP). exhibited depressant action of on the CNS. Apart from them a mildto moderate degree of depression was evident as a consequence of administration of Zingiberofficinale Rosc (SUT), Piper nigrum L. (MRC). However, none of the plant tested did not exhibitsignificant effects on pentobarbital induced narcosis, and this indicated that the sedating effects ofthe drug was not associated with the risk of fatal consequences on overdose.