Neuropharmacological study of some Ayurvedic medicinal plants > Volume 03 - 2003

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Oriental Pharmacy and Experimental Medicine
Volume 03 - 2003
Date: 2003

Journal: Pages 8-17

Fevruary 2003 | Neuropharmacological study of some Ayurvedic medicinal plants…

JMA Hannan1, Masum Shahriar2,*, M Naimul Islam3, Mafruhi Sattar3, Sabera Haque3 and MSK Choudhuri3

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Summary

​Water extract (kwath) of six different widely used Ayurvedic medicinal plants were tested inmice for possible neuropharmacological efficacy. In the present experiments it was observed thata number of plant tested causes a significant level of Central Nervous System (CNS) depression,in that it significantly decreased the spontaneous Motor activity, and also lowered the exploratorybehavior of the treated animals. Terminalia chebula (HAA), Terminalia bellerica (BHA), Emblicaofficinalis (AA), Piper longum L. (PP). exhibited  depressant action of on the CNS. Apart from them a mildto moderate degree of depression was evident as a consequence of administration of Zingiberofficinale Rosc (SUT), Piper nigrum L. (MRC). However, none of the plant tested did not exhibitsignificant effects on pentobarbital induced narcosis, and this indicated that the sedating effects ofthe drug was not associated with the risk of fatal consequences on overdose.


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