The pharmacological effects of an Ayurvedic diuretic drug “Treenoponchomul” (TPM) wasinvestigated in animal model. The pharmacological actions of the test drug along with that of thecomponents thereof, on the Central Nervous System (CNS) were studied. The drug under studyTPM showed little effect on the CNS, the same can not be said about the components. The mostprominent CNS depressant effect was observed with Saccharum officinarum Linn. (EE) in that itlowered the spontaneous motor activity as well the exploratory -behavior of the animals. Anexploration retarding effect of moderate degree, was evident with Imperata cylindrica Beauv. (UU),and Phragmites maxima Blatter & McCann (NN). Although the test drug did not alter the normallocomotor and/or exploratory behavior of the treated animals, it did significantly (p<0.01) lowerthe locomotion of the amphetamine induced hyperactive animals. TPM along with itscomponents (especially Desmostachya bipinnata Stapf. Root, KU), significantly reduced thegastro-intestinal motility of the treated animals (p<0.01). The test drug and its componentslowered the body weight of the treated animals, on being administered chronically (30 days),with EE being the only exception.