Sense-line (SL), a dietary functional food, is our invention for weight loss. To evaluate such aneffect of SL, we analyzed the plasma levels of total cholesterol, low-density lipoprotein (LDL)cholesterol, high-density lipoprotein (HDL) cholesterol, and weight changes after rats were fed onhigh fat diet with SL for 20 days. Plasma total cholesterol level and LDL-cholesterol level wasdecreased by 52% and 91.89% in 5% SL treated group and by 13% and 51.45% in 10% SL treatedgroup, respectively. But HDL-cholesterol was not changed. In addition, the weight was significantlylower in SL group than in high-fat diet group (P<0.05). Our findings indicate that SL may containcompounds with actions, which can treat blood circulatory trouble as well as overweight.