Resibufogenin induces cardiac arrhythmia > Volume 03 - 2003

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Oriental Pharmacy and Experimental Medicine
Volume 03 - 2003
Date: 2003

Journal: Pages 51-55

May 2003 | Resibufogenin induces cardiac arrhythmia…

Jing-Tian Xie1,2, Sangeeta R. Mehandale1,2, Spring A. Malechar1,2 and Chun-Su Yuan1,2,3*

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Summary

​Resibufogenin is a single compound isolated from the skin venom gland of the toad (Bufo bufogargarizans cantor). Formulations containing toad venom have been widely used as complementary andalternative medicines. However, like digitalis, resibufogenin possesses both pharmacological andtoxicological activities. Our previous data indicated that resibufogenin induces electro-toxicity,including delayed afterdepolarization and triggered arrhythmias at high concentration, both incardiac fiber in vitro and in beating heart in vivo.


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