Effect of Terminalia chebula fruit on anaphylaxis by anal therapy > Volume 03 - 2003

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Oriental Pharmacy and Experimental Medicine
Volume 03 - 2003
Date: 2003

Journal: Pages 56-62

May 2003 | Effect of Terminalia chebula fruit on anaphylaxis by anal therapy…

Hye-Young Shin1, Kyung-Bo Lee2, Yun-Hee Jung2, Eun-Ah Kim2, Mi-Young Lee2, Mi-Ri Lee2, Sang-Yong Kim3, Sang-Hyun Kim4 and Tae-Yong Shin2,*

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Summary

​The effect of aqueous extract of Terminalia chebula fruit (Combretaceae) (TCAE) by anal administration onmast cell-dependent immediate-type anaphylactic reactions was investigated. TCAE (0.005 to 1g/kg) inhibited systemic anaphylaxis induced by compound 48/80 in mice. When TCAE waspretreated at the same concentrations with systemic anaphylaxis, the plasma histamine levelswere reduced in a dose-dependent manner. TCAE (0.1 and 1 g/kg) also significantly inhibited localanaphylaxis activated by anti-DNP IgE. TCAE (0.001 to 1mg/ml) dose-dependently inhibited thehistamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. Moreover, TCAE (0.01 and 0.1mg/ml) had a significant inhibitory effect on anti-DNPIgE-mediated tumor necrosis factor-a (TNF-a) production from RPMC. These results provideevidence that anal therapy of TCAE may be beneficial in the treatment of systemic and local mastcell-dependent anaphylaxis.


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