Systematic analysis of caffeine from the commercial samples of Indian tea leaves was performedby a routine method and the content of caffeine was found to be 19.0-37.4 mg/100 g leaves. Thecaffeine contents from coffee seeds and chicory from Indian origin were analyzed and found to be0.6540-1.4920 g/100 g seeds. Caffeine contents of roasted Indian chicory roots were lower thaneither those of Indian tea leaves or Indian coffee seeds. The multidrug resistance (MDR) reversingeffects were tested on a mouse leukemia cell line of L-5178 cells by methanol extracts [M1-M15] ofIndian tea leaves and coffee seeds, comparing to a control of (±)-verapamil. The effects weremeasured by fluorescence ratio between treated and untreated group cells. Among fifteenmethanol extracts, a Gemini tea [M6] (fluorescence activity ratio 5.26) had the most potent effectfor L-5178 cells. The extract M6 was 0.63-fold of (±)-verapamil. We suggest that one ofmechanisms of reversal by M6 might have strong affinity to dopamine D1 and D2 receptors.Further studies with many more tumor and normal cell lines are necessary to confirm the MDRreversal specificity of coffee methanol extracts.