Plants of the genus Hypericum (Family-Hypericaceae) are herbs, shrubs or small trees and aredistributed chiefly in the temperate regions of the world. About 400 different species of Hypericumare available throughout the globe and 20 species occur in India, including a few cultivated ingardens. Almost all plants of the genus Hypericum are widely used in folk medicine. Severalpotent phytoconstituents from different Hypericum species have led to the isolation ofantibacterial, antifungal and cytotoxic compounds. With the development of resistance and crossresistance with different microorganisms and the evolution of so many deadly diseases thescreening and evaluation of the phytoconstituents so much so the development of variedphytoconstituents for the drug development for these deadly diseases is utmost essential in everyaspects. The present review on the antimicrobial use of different Hypericum reports the findingsfrom and extensive literature search on the Hypericum species around the globe that have beenassessed for antimicrobial and antiviral activity. An attempt has been made through this reviewto summarize the information in this aspect in order to highlight the promising species of thisgenus which are worthy for further investigation as leads for drug development. Over 31different Hypericum species have been reported to possess such activities with their variednumber of phytoconstituents. Sixteen different constituents of six different classes ofphytoconstituents have been reported to be present in different varieties of Hypericum, whichmay be considered responsible for this activity.