Some pharmacological studies with Cycleanine, a diphenylbisbenzylisoquinolinealkaloid from Stephania hernandifolia > Volume 03 - 2003

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Oriental Pharmacy and Experimental Medicine
Volume 03 - 2003
Date: 2003

Journal: Pages 123-128

September 2003 | Some pharmacological studies with Cycleanine, a diphenylbisbenzylisoquinolinealkaloid from Stephania hernandifolia…

Suparna Maitra1, Tapan Seal4, Sujit Mallik1, Arnab Khasnobis1, RP Nandi2, J Rajan Vedasiromoni3 andBiswapati Mukherjee4,*

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Summary

​Stephania hernandifolia belonging to the family Menispermaceae is the biggest storehouse ofdiphenylbisbenzylisoquinoline (DBBI) alkaloids. Exhaustive chemical processing of the bulb of S.hernandifolia by the application of modern separation techniques yielded a DBBI alkaloid whichwas identified as cycleanine using spectroscopic methods (UV, IR, 1HNMR. 13CNMR, Mass). Cycleanineshowed significant anti-inflammatory activity against carrageenin induced paw oedema,comparable to that produced by diclofenac sodium, used as standard drug. It exhibited potentanalgesic effects against chemical and thermal noxious stimuli. It was also found to possess anti-convulsive activity in the strychnine induced convulsion model.


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