Petroleum ether, chloroform and ethanol extracts of the seeds of Melia azedarach Linn.administered orally to male rats at the dose level of 25 mg/100 g body weight for 48 days showedantispermatogenic activity, as the number of spermatocytes, spermatids and spermatozoa wasdecreased. The total cholesterol content was increased while protein and glycogen contents weredecreased. The acid phosphatase content was also decreased while that of alkaline phosphataseincreased. At the same time the weight of caput and cauda epididymis, prostate gland, seminalvesicle and Levator Ani muscle was decreased indicating its antiandrogenic property. Of thethree extracts, the petroleum ether extract was more potent in its antispermatogenic andantiandrogenic activities and did not produce any sings of toxicity upto a dose of 25 mg/100 gbody weight oral administration. After subjecting it to preliminary phytochemical screening thepetroleum ether extract showed positive tests for steroids and saponins.