The effects of ethanol extract of Ruta graveolens on ulceration induced by ethanol and woundhealing properties were investigated in mice. Oral administration of the extract reduced theincidence of ulcer, ulcer index and ulcer length produced by ethanol. The gastroprotective effectsof R. graveolens were observed in a dose-dependent manner. However, this activity wasstatistically less potent than the anti-ulcer drug, omeprazole. When the extract applied on thewound, it promoted wound healing in mice. The wound contraction was faster in these micewhen compared to untreated wounds. Based on these present findings, R. graveolens possessesanti-ulcer activity and promotes incision wound healing in mice.