Anti-ulcer and wound healing activity of Ruta graveolens > Volume 03 - 2003

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Oriental Pharmacy and Experimental Medicine
Volume 03 - 2003
Date: 2003

Journal: Pages 147-150

September 2003 | Anti-ulcer and wound healing activity of Ruta graveolens…

Nhareet Somchit*, Shamima A Rahman, Zuraini Ahmad and Abdul Salam Abdullah1

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Summary

​The effects of ethanol extract of Ruta graveolens on ulceration induced by ethanol and woundhealing properties were investigated in mice. Oral administration of the extract reduced theincidence of ulcer, ulcer index and ulcer length produced by ethanol. The gastroprotective effectsof R. graveolens were observed in a dose-dependent manner. However, this activity wasstatistically less potent than the anti-ulcer drug, omeprazole. When the extract applied on thewound, it promoted wound healing in mice. The wound contraction was faster in these micewhen compared to untreated wounds. Based on these present findings, R. graveolens possessesanti-ulcer activity and promotes incision wound healing in mice.


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