The Hexane Extract (HE) and Ethyl Acetate Soluble Fraction of the Methanolic Extract (EASFME)of the fruit pulp of Momordica dioica Roxb. (Cucurbitaceae) was evaluated for its anti-hepatotoxicactivity in rats. Acute hepatotoxicity was induced by administering paracetamol (2g/kg, p.o.) for3 days. The extracts, at a dose of 400mg/kg (p.o.) administered for 7 days exhibited a significanttherapeutic effect by lowering Serum Glutamate Oxaloacetate Transaminase (SGOT), SerumGlutamate Pyruvate Transaminase (SGPT), Serum Alkaline Phosphatase (ALP) and Serum bilirubin andincreasing the serum protein levels. These biochemical observations were supplemented byhistopathological examination of the liver sections. The activity of extract was also comparable tothe standard drug Silymarin, which is a well-known natural anti-hepatotoxic drug.