Invitro antifilarial potential of the leaf extract of Oscimum sanctum on cattlefilarial parasite Setaria cervi > Volume 04 - 2004

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Oriental Pharmacy and Experimental Medicine
Volume 04 - 2004
Date: 2004

Journal: Pages 53-59

March 2004 | Invitro antifilarial potential of the leaf extract of Oscimum sanctum on cattlefilarial parasite Setaria cervi…

Rizvi Waseem, Singhal KC, Haider Nakhat and Kumar Anil

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Summary

​The effect of aqueous and alcoholic extract of the leaves of Ocimum. sanctum was studied on thespontaneous movements of the whole worm (w.w) preparation and nerve muscle (n.m.) complexof Setaria cervi (S. cervi) and on the survival of microfilariae (m.f.) in vitro. Both the extractscaused inhibition of the spontaneous motility of the w.w. and n.m. complex of S. cervicharacterized by initial stimulation followed by reversible paralysis, aqueous extract at a higherconcentration showed immediate effect and irreversible paralysis. The concentration required toinhibit the movements of n.m. complex was 1/4th for aqueous and 1/3rd for alcoholic extractcompared to that for the w.w., suggesting a cuticular permeability barrier. On the m.f. the lethalconcentration (LC 50 and LC 90) were 35 and 50 ng/ml for aqueous whereas, 60 and 85 ng/ml foralcoholic extracts respectively.


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