Pethidine induced changes in ovarian follicular kinetics and biochemicalparameters in albino rats > Volume 05 - 2005

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Oriental Pharmacy and Experimental Medicine
Volume 05 - 2005
Date: 2006

Journal: Pages 300-305

December 2006 | Pethidine induced changes in ovarian follicular kinetics and biochemicalparameters in albino rats…

Vijaykumar B Malashetty1,*, Somanath Reddy Patil2 and Saraswati B Patil2

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Summary

​Pethidine at the dose level of 0.5 mg and 0.75 mg/100 g body weight administered for 20 days tothe cycling albino rats caused decrease in the ovarian weight and its protein content. The ovarianfolliculogenesis in treated rats is hampered; as a result the follicles which are at the differentstages of growth underwent regression. Therefore, the number of healthy follicles is reduced andatretic follicles increased. The elevated levels of ovarian cholesterol and decreased level ofglycogen in the pethidine treated rats indicates the inhibition brought in steroidogenesis, which isdependent on pituitary gonadotrophins.


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