Antioxidant and analgesic activity of Clerodendrum viscosum leaf > Volume 05 - 2005

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Oriental Pharmacy and Experimental Medicine
Volume 05 - 2005
Date: 2006

Journal: Pages 319-323

December 2006 | Antioxidant and analgesic activity of Clerodendrum viscosum leaf…

Shafiur Rahman1,*, Mokaddez Sarder1, Jamil Ahmad Shilpi1 and Choudhury Mahmud Hasan2

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Summary

​The crude ethanolic extract of the leaves of Clerodendrum viscosum (Family: Verbenaceae) wasevaluated for its antioxidant and analgesic activities to investigate the scientific basis of thetraditional uses. The antioxidant property of the extract was assessed by 1, 1-diphenyl -2- picrylhydrazyl (DPPH) free radical scavenging assay. The extract showed prominent antioxidantactivity (IC50 about ~ 16 µg/ml), which was comparable to standard drug ascorbic acid (IC50 about~15 µg/ml). The extract produced significant (P < 0.001) writhing inhibition in acetic acid inducedwrithing in mice at the dose of 125 mg, 250 mg and 500 mg/kg body weight respectively, whichwere comparable to the standard drug diclofenac sodium. The results tend to suggest that thecrude leaves extract at the above doses have antioxidant and analgesic activities and indicate thatit might possess biologically active constituents having free radical scavenging and analgesicactivities respectably.


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