Ginseng is a popular medicinal plant highly valued throughout the world. Asian ginseng is one ofthe most common species of ginseng. It has long occupied a significant position in orientalmedicine and has been justified its name as the “king herb”. As a nutritional supplement, ginsengis an extremely common and popular herbal medicine in the United States and Canada in recentdecades. The multiple constituents of ginseng possess equally multifaceted pharmacological actions asdemonstrated by numerous studies. Ginseng root and its constituents influenced the central nervoussystem, endocrine, cardiovascular, gastrointestinal system, sexual, renal organ and immune system,etc. One important action is its anti-hyperglycemic effect. Previous studies on ginseng demonstrate thatonly the root of ginseng has been used in the treatment of diabetes, while the other parts ofginseng plant were always neglected. Recently, we analyzed the constituents of ginseng berry,leaf and discovered that ginseng berry, leaf extracts and its total ginsenosides have the ability toreduce hyperglycemia and body weight and increase the peripheral glucose utilization in obeseor diabetic ob/ob or db/db mice. Our data suggest that all parts of ginseng plant, including root,berry, leaf and stem exhibit potent anti-hyperglycemic and anti-obese effects and may provide anopportunity to develop a novel class of anti-diabetic agents.