Ethanol and aqueous extracts of Cassia auriculata were tested in vitro against fungi (Candidaalbicans and Microsporum canis) and bacteria (Escherichia coli, Salmonella enteriditis, Staphylococcusaureus and Bacillus subtilis). M. canis showed dose-dependent susceptibility only towards ethanolleaf and bark extracts. C. albicans, were resistant to all types of plant extracts. Results werestatistically smaller to antifungal drug ketoconazole and miconazole at equivalent concentration.Both ethanol and aqueous extracts of Cassia auriculata leaves and barks exhibit antibacterialactivity against S. aureus and only the ethanol extracts of leaf and bark were detected againstBacillus subtilis. The results were compared to antibacterial drugs chloramphenicol, ampicillin,penicillin G, and enrofloxacin. The antibacterial activity was statistically similar to penicillin G.Based on the current findings, it can be concluded that this plant has antimicrobial activity, whichis as potent as standard antimicrobial drugs.