Anti-allodynic effect of bee venom on neuropathic pain in the rat > Volume 05 - 2005

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Oriental Pharmacy and Experimental Medicine
Volume 05 - 2005
Date: 2006

Journal: Pages 324-329

December 2006 | Anti-allodynic effect of bee venom on neuropathic pain in the rat…

Bae Hwan Lee1,†, Younbyoung Chae2,†, Hye Jeong Hwang2, Young-Kook Choi2, Dae Hyun Hahm2, Seung-Moo Han3, Sung-Keel Kang4, Hye-Jung Lee2, Kwang-Ho Pyun5 and Insop Shim5,*

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Summary

​Neuropathic pain syndromes resulted from peripheral nerve injury appear to be resistant toconventional analgesics like opioids. However, it has been demonstrated that acupunctureincluding aqua-acupuncture may be effective in managing neuropathic pain. The present studywas conducted to determine if bee venom injection into acupoint inhibits neuropathic pain, whichis difficult to be treated by usual analgesics. Under pentobarbital anesthesia, male Sprague-Dawley rats were subjected to neuropathic surgery. Two weeks after nerve injury, mechanicaland cold allodynia were tested in order to evaluate the antiallodynic effects of bee venominjection into an acupoint. Intraperitoneal injection of morphine inhibited mechanical allodyniadose-dependently. Bee venom injected into Zusanli acupoint significantly inhibited mechanicaland cold allodynia. These results suggest that bee venom-acupuncture as well as morphine isvery effective to inhibit mechanical allodynia.


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