In vitro antifilarial potential of the leaves and stem extract of Pluchealanceolata on the cattle filarial parasite Setaria cervi > Volume 05 - 2005

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Oriental Pharmacy and Experimental Medicine
Volume 05 - 2005
Date: 2005

Journal: Pages 110-116

June 2005 | In vitro antifilarial potential of the leaves and stem extract of Pluchealanceolata on the cattle filarial parasite Setaria cervi…

Vandna Mishra1, Nazneen Parveen2, Nizam U Khan1,* and KC Singhal3

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Summary

​The effect of alcohol and aqueous extracts of the leaves and stem of Pluchea lanceolata on thespontaneous movements of both the whole worm and the nerve muscle preparation of Setariacervi, and on the survival of microfilariae in vitro was studied. Alcohol and aqueous extracts of theleaves and stem of P. lanceolata caused the inhibition of spontaneous movements of the wholeworm and the nerve muscle preparation of S. cervi, characterized by short lasting small increase intone and amplitude of contractions followed by paralysis. The concentrations required to inhibitthe movements of whole worm and nerve muscle preparations for alcohol extract were 200 and 25µg/ml, and for aqueous extract were 250 and 100 µg/ml, respectively, suggesting a cuticularpermeability barrier. Both the extracts (alcohol and aqueous) caused death of microfilariae invitro, LC50 and LC90 being 12 and 18 ng/ml for alcohol extract and 25 and 40 ng/ml for aqueousextract, respectively.


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