Experimental research for the protective effect of Naoxingtong-containingserum on rat cerebral microvascular endothelial cells > Volume 05 - 2005

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Oriental Pharmacy and Experimental Medicine
Volume 05 - 2005
Date: 2005

Journal: Pages 156-159

June 2005 | Experimental research for the protective effect of Naoxingtong-containingserum on rat cerebral microvascular endothelial cells…

Zhou Jun1, Guo Jianyou1, Guo Jian2, Li Lanfang1, Li Canghai1, Jiang Nan1, Guo Shuying1, Huo Hairu1and JiangTingliang1,*

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Summary

​The protective effect of Naoxingtong (NXT) on rat cerebral microvascular endothelial cell(rCMEC) was investigated. rCMEC was injured in vitro by incubating for 4 hours at 100% NO in ahypoxia chamber. After treated with NXT-containing serum, the cellular viability rate (90.3%)was significantly elevated when compared with that of control group and the inhibitive rate oflactic dehydrogenase (LDH) activity (9.2%) was far lower than the control group with dose-dependent effect. The results indicate that NXT can increase viability of rCMEC, and protect cellmembrane from injury during hypoxia.


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