Inhibitory effect of Anglicae dahuricae radix on mast cell mediatedinflammatory responses > Volume 05 - 2005

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Oriental Pharmacy and Experimental Medicine
Volume 05 - 2005
Date: 2005

Journal: Pages 188-194

September 2005 | Inhibitory effect of Anglicae dahuricae radix on mast cell mediatedinflammatory responses…

Jong-Ha Park1, In-Young Choi2,3, Ho-Jeong Na2,3, Hyun-Ja Jeong2,3, Seong-Guem Ko2, Byung-Hee Lee2,Yong-Sun Song1, Hyung-Min Kim3, Seung-Heon Hong2 and Jae-Young Um3,*



​The Angelicae dahuricae radix (ADR) has been used a traditional medicine to treat acne, erythema,headache, toothache, sinusitis, colds, and flu in Korea, Japan and China. Here, we report the effectof ADR on compound 48/80-induced ear-swelling and the phorbol myristate acetate (PMA) pluscalcium ionophore A23187-induced inflammatory cytokine secretion in the human mast cell line,HMC-1. ADR dose-dependently inhibited the ear-swelling response induced by intradermalinjection of compound 48/80. In vitro model, PMA plus A23187 significantly increasedinterleukin (IL)-1β, IL-8, granulocyte macrophage colony stimulating factor (GM-CSF), and tumornecrosis factor (TNF)-α secretion compared with media control. We also show that the increasedcytokines IL-1β, IL-8, GM-CSF, and TNF-α level was significantly inhibited by treatment of ADR.In addition, ADR partially blocked PMA plus A23187-induced extracelluar signal-regulatedkinases phosphorylation. These results suggest that ADR might explain its beneficial effect in thetreatment of mast cell-mediated inflammatory diseases.

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