The crude methanolic extract of the bark of Cerbera odollam Gaertn. was evaluated for its possibleantinociceptive and neuropharmacological activities in animal models. At the dose of 250 and 500mg/kg body weight, the extract showed a significant antinociceptive effect in acetic acid inducedwrithing in mice comparable to that produced by aspirin, used as standard drug (P < 0.001). Theextract significantly reduced the time of onset of sleep (P < 0.01) and potentiated the pentobarbitalinduced sleeping time in mice at the dose of 400 mg/kg of body weight significantly (P < 0.001). Italso decreased the open field score in open field test significantly at the dose of 400 mg/kg ofbody weight (P < 0.05). The obtained results tend to suggest the probable antinociceptive andneuropharmacological activities of the crude extract.