Antinociceptive and sedative effects of the bark of Cerbera odollam Gaertn. > Volume 05 - 2005

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Oriental Pharmacy and Experimental Medicine
Volume 05 - 2005
Date: 2006

Journal: Pages 344-348

December 2006 | Antinociceptive and sedative effects of the bark of Cerbera odollam Gaertn.…

Firoj Ahmed, M Hemayet Hossain, Ahmed Ayedur Rahman and Israt Zahan Shahid*

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Summary

​The crude methanolic extract of the bark of Cerbera odollam Gaertn. was evaluated for its possibleantinociceptive and neuropharmacological activities in animal models. At the dose of 250 and 500mg/kg body weight, the extract showed a significant antinociceptive effect in acetic acid inducedwrithing in mice comparable to that produced by aspirin, used as standard drug (P < 0.001). Theextract significantly reduced the time of onset of sleep (P < 0.01) and potentiated the pentobarbitalinduced sleeping time in mice at the dose of 400 mg/kg of body weight significantly (P < 0.001). Italso decreased the open field score in open field test significantly at the dose of 400 mg/kg ofbody weight (P < 0.05). The obtained results tend to suggest the probable antinociceptive andneuropharmacological activities of the crude extract.


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