Effects of Naoxintong-containing serum on NO and CGRP in rat cerebralmicrovascular endothelial cells > Volume 05 - 2005

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Oriental Pharmacy and Experimental Medicine
Volume 05 - 2005
Date: 2005

Journal: Pages 236-239

September 2005 | Effects of Naoxintong-containing serum on NO and CGRP in rat cerebralmicrovascular endothelial cells…

Li Lanfang1, Li Canghai1, Dang Haixia2, Jiang Nan1, Guo Jianyou1, Guo Shuying1, Huo Hairu1 andJiang Tingliang1,*

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Summary

​Effects of Naoxintong (NXT, a formula of Chinese Materia Medica)-containing serum on Nitrogenmonoxide (NO) and calcitonin gene related peptide (CGRP) in rat cerebral microvascularendothelial cells (rCMEC) was investigated. rCMEC was injured in vitro by incubating for 4 hoursat 100% NO in a hypoxia chamber. The results indicated that NXT could antagonize the reductionof NO and CGRP secreted by rCMEC during hypoxia, the effect of which was dose-dependent.After treated with NXT-containing serum at dosage of 5.0 - 3.0 and 5.0 - 1.1 g/kg/U respectively,the amount of NO and CGRP secreted by rCMEC were remarkably increased during hypoxiain vitro.


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