Antifilarial activity of Nigella sativa on Setaria cervi-an in vitro study > Volume 05 - 2005

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Oriental Pharmacy and Experimental Medicine
Volume 05 - 2005
Date: 2005

Journal: Pages 240-245

September 2005 | Antifilarial activity of Nigella sativa on Setaria cervi-an in vitro study…

Waseem Rizvi*, Anil Kumar, NH Rizvi, Razi Ahmad, KC Singhal and Atif Khan

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Summary

​The effect of aqueous and alcoholic extract of seeds of Nigella sativa (N. sativa) was studied on thespontaneous movements of the whole worm (w.w) preparation and nerve muscle (n.m) complexof Setaria cervi (S. cervi). Both the extracts caused inhibition of spontaneous movements of the w.wand n.m complex characterized by initial stimulation followed by irreversible paralysis, with theexception that aqueous extract produced a partially reversible paralysis of w.w preparation.Lesser concentration of both the extracts was required to inhibit the movements of n.m complexthan the w.w. Suggesting a cuticular permeability barrier. The lethal concentration 50 (LC50) andlethal concentration 90 (LC90) were 30 and 55 ng/ml for aqueous and 45 and 60 ng/ml foralcoholic extracts respectively.


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