Can herbal drug(s) meet the challenges of genomewide screen results onrheumatoid arthritis > Volume 05 - 2005

본문 바로가기

사이트 내 전체검색


 » New Articles(2011~Present)
 » Articles (2001~2010)
      ∙ Volume 10 - 2010
      ∙ Volume 09 - 2009
      ∙ Volume 08 - 2008
      ∙ Volume 07 - 2007
      ∙ Volume 06 - 2006
      ∙ Volume 05 - 2005
      ∙ Volume 04 - 2004
      ∙ Volume 03 - 2003
      ∙ Volume 02 - 2002
      ∙ Volume 01 - 2001
 

Oriental Pharmacy and Experimental Medicine
Volume 05 - 2005
Date: 2005

Journal: Pages 251-261

December 2005 | Can herbal drug(s) meet the challenges of genomewide screen results onrheumatoid arthritis…

Bholanath Paul

첨부파일

Summary

​Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder with a complex geneticcomponent. RA is characterized by chronic inflammation of the synovial membrane in the joint,which leads to the progressive destruction of articular cartilage, ligament and bone. Severalcytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6)have been implicated in the pathological mechanisms of synovial tissue proliferation, jointdestruction and programmed cell death in rheumatoid joint. Genome wide screening of subjectssuffering from autoimmune diseases especially arthritis revealed linkage to inflammatorymolecules like TNF-α, IL-1β and IL-6, inducible nitric oxide synthase (iNOS), cyclooxygenase-2(COX-2 ), nuclear factor-kappaB (NF-κB) and human leucocyte antigen/major histocompatibilitycomplex (HLA/MHC) locus. The status of the pharmacological mechanism of herbal drugs in thelight of genome wide screening results has been discussed to reinforce the therapeutic potentialand the pharmacological basis of the herbal drugs.


This website Copyright (c) 2014 Institute of Korean Medicine Kyung Hee University All rights reserved.
Top View
Mobile View