Piper betle Linn. (PB), which belongs to the family Piperaceae, is used traditionally in many Asiancountries for treatment of a variety of aliments. It has also been used in Ayurveda and Unanisystems of medicine. PB leaves are also used as a masticatory in the form of quid. The basicpreparation of PB leaves for chewing purposes (PB quid) is known as Paan in India. It isrecommended in ancient scripture of Ayurveda and is closely associated with Indian culture. PB isreported to have several therapeutic potentials as well as to produce some untoward effects. The reviewdeals with phytoconstituents present, therapeutic potentials and untoward effects of PB.