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Oriental Pharmacy and Experimental Medicine
Volume 05 - 2005
Date: 2005

Journal: Pages 301-307

December 2005 | Anxiolytic activity of standardized extract of Korean ginseng - a study onexploratory behavior…

M Mohan1,*, SB Kasture2 and R Balaraman3

첨부파일

Summary

​The roots of the plant Korean ginseng have been extensively used in the traditional Chinese herbalmedicine. We investigated the standardized extract of Korean ginseng on animal models of anxietybased on exploratory behavior. Korean ginseng extract (KGE) (3, 10 and 30 mg/kg) wasadministered intra-peritoneally. The anxiolytic activity was studied using elevated plus maze(EPM) paradigm, light/dark apparatus (LDA), open field apparatus (OFA) and the hole boardapparatus (HBA). Diazepam (1mg/kg) was used as a standard anxiolytic drug. In EPM, KGE (10mg/kg) significantly (P < 0.05) increased the time spent in open arms and the number of entries inopen arms. In LDA, KGE (10 mg/kg) increased the number of transitions. In OFA, KGE (3 and 10mg/kg) significantly increased (P < 0.05) the number of squares traversed. In HBA the number ofhead pokes were significantly increased with KGE (3 and 10 mg/kg). KGE at all selected dosesdid not affect the motor coordination. Thus, the study suggests that saponin containingstandardized Korean ginseng extract possess anxiolytic activity.


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