Effects of Panax notoginseng, ginsenoside Rb1, and notoginsenoside R1 onproliferation of human breast carcinoma MCF-7 cells > Volume 05 - 2005

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Oriental Pharmacy and Experimental Medicine
Volume 05 - 2005
Date: 2006

Journal: Pages 286-292

December 2006 | Effects of Panax notoginseng, ginsenoside Rb1, and notoginsenoside R1 onproliferation of human breast carcinoma MCF-7 cells…

Jing-Tian Xie1,2, Han H Aung1,2, Chong Zhi Wang1,2, Sangeeta R Mehendale1,2, Eryn McEntee1,2, Sheila Wicks1,2, Jing Li3 and Chun-Su Yuan1,2,4,*

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Summary

​In this study, we evaluated the antiproliferative effects of Panax notoginseng, ginsenoside Rb1, andnotoginsenoside R1 in the human breast carcinoma MCF-7 cell line. Our results indicated thatboth Panax notoginseng radix extract (NRE) and Panax notoginseng rhizoma extract (NRhE) possesssignificant antiproliferative activities in MCF-7 cells. Compared to control group (100%), at theconcentrations of 0.05, 0.5, and 1.0 mg/ml NRE, cell growth was concentration-dependentlyreduced to 81.0 ± 6.1 (P < 0.01), 34.2 ± 4.8 (P < 0.001), and 19.3 ± 1.9 (P < 0.001), respectively.Similar results with NRhE at concentrations of 0.5 and 1.0 mg/ml were obtained in these MCF-7cells. To identify the responsible chemical constituent, we tested the antiproliferation effects oftwo representative saponins, ginsenoside Rb1 and notoginsenoside R1, on the MCF-7 cells. Thedata showed that ginsenoside Rb1 was endowed with antiproliferative properties, whilenotoginsenoside R1 did not have an inhibitory effect in the concentrations tested. Our studiesprovided evidence that Panax notoginseng extracts and ginsenoside Rb1 may be beneficial, asadjuvants, in the treatment of human breast carcinoma.


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