Effects of opioid and non-opioid antagonists, pH and enzymes on Corchorusolitorius antinociception in mice > Volume 06 - 2006

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Oriental Pharmacy and Experimental Medicine
Volume 06 - 2006
Date: 2006

Journal: Pages 186-195

September 2006 | Effects of opioid and non-opioid antagonists, pH and enzymes on Corchorusolitorius antinociception in mice…

Zainul Amiruddin Zakaria1,*, M Neelendran1, S Pubalan1, MR Sulaiman2 and CA Fatimah1

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Summary

​The present study was carried out to determine the involvement of opioid and non-opioidreceptor and the effect of pH and enzymes on the recently reported antinociceptive activity ofaqueous extract of Corchorus olitorius (AECO) leaves using the abdominal constriction test. Theextract was prepared by soaking the dried powdered leaves of Corchorus (C.) olitorius in distilledwater overnight, and the supernatant obtained was considered as a stock solution with 100%concentration/strength. The extract, administered subcutaneously in the concentrations/strengthof 10, 50 and 100%, was found to show a significant concentration-independent antinociception.The 50% concentration AECO were further used to study on the above mentioned parameters.The extract exhibited: significant (P < 0.05) decreased in activity when pre-treated (s.c.) against10mg/kg naloxonazine, bicuculine (10 mg/kg), phenoxybenzamine (10 mg/kg), 10 mg/kg pindolol,and 5 mg/kg mecamylamine, but not 10 mg/kg naltrindole, 10 mg/kg atropine, respectively;significant (P < 0.05) decreased in activity after pre-treatment against 10% a-amylase, but not 1%protease or 10% lipase and; significant (P < 0.05) decreased in activity after exposure to alkalinecondition (pH between 9 and 13) while maintaining the activity at acidic condition, respectively.The C. olitorius leaves antinociception, which involved, at least in part, activation of µ-opioid,α- and β-adrenergic, and nicotinic receptors, was found to decrease under alkaline condition andin the presence of α-amylase.


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