Hepatoprotective effect of kasni against aflatoxin B1 induced hepatic damagein mice > Volume 06 - 2006

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Oriental Pharmacy and Experimental Medicine
Volume 06 - 2006
Date: 2006

Journal: Pages 196-201

September 2006 | Hepatoprotective effect of kasni against aflatoxin B1 induced hepatic damagein mice…

Farah Naaz2, MZ Abdin2 and Saleem Javed1,*

첨부파일

Summary

​The efficacy of alcoholic extract of Kasni (Cichorium intybus L.) to control hepatic damage inducedby aflatoxin B1 was explored in Swiss albino mice. Aflatoxin B1 was administered orally to the micewith a daily dose of 66.6µg/kg body weight till three months. A signifi-cant increased in thiobarbituric acid reactive substances (TBARS) levels with concomitant reduction in enzymatic(glutathione-s-transferase, glutathione peroxidase, superoxide dismutase, and catalase) and non-enzymatic (reduced glutathione) antioxidants were shown in aflatoxin treated group of mice.However, there was a significant reduction in increased TBARS levels and elevation in enzymaticand non enzymatic antioxidant levels in group of mice which received alcoholic extract of kasni(300mg/kg bw/day) along with aflatoxin. Histopathological analysis of liver samples also confirmedthe hepatoprotective effect of kasni extract. These results suggest that kasni shows hepatoprotective effectagainst aflatoxin B1 induced hepatic damage in mice.


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