The crude methanol extract of the roots of Achyranthes aspera Linn. was investigated for itspossible antinociceptive, diuretic and neuropharmacological activities in animal models. At thedose of 250 and 500 mg/kg body weight, the extract showed a significant antinociceptive effect inacetic acid induced-writhing in mice comparable to that produced by diclofenac sodium, used asstandard drug. The crude extract produced significant diuretic effect at the dose of 500 mg/kg ofbody weight comparable to that produced by furosemide, used as standard drug. The extract alsopotentiated significantly the pentobarbital induced sleeping time in mice; decreased the openfield score in open field test, decreased the number of hole crossed from one chamber in the holecross test and decreased the head dip responses. The obtained results provide a support for theuse of this plant in traditional medicine and its further investigation.