Central nervous system activity of the methanol extracts of Caesalpiniabonducella and Bauhinia racemosa (Caesalpinaceae) in experimental animalmodel > Volume 06 - 2006

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Oriental Pharmacy and Experimental Medicine
Volume 06 - 2006
Date: 2006

Journal: Pages 221-231

September 2006 | Central nervous system activity of the methanol extracts of Caesalpiniabonducella and Bauhinia racemosa (Caesalpinaceae) in experimental animalmodel…

Ramanathan Sambath Kumar1,2,*, Thangavel Sivakumar1, Rajagopal Shanmuga Sundaram1, PeriyasamyGomathi2, Mani Senthil Kumar2, Upal Kanti Mazumdar2 and Malaya Gupta2

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Summary

​The aim of the present study is to investigate central nervous system (CNS) activity of themethanol extracts of leaves of Caesalpinia bonducella (MECB) and stem bark of Bauhinia racemosa(MEBR) (Caesalpinaceae) in Swiss albino mice and Wistar albino rats. General behavior, exploratorybehavior, muscle relaxant activity and phenobarbitone sodium–induced sleeping time were studied. Theresults revealed that the methanol extracts of leaves of Caesalpinia bonducella at 100–200 mg/kg and stembark of Bauhinia racemosa 100 – 200 mg/kg caused a significant reduction in the spontaneous activity(general behavioral profile), remarkable decrease in exploratory behavioral pattern (Y–maze andhead dip test), a reduction in muscle relaxant activity (rotarod and traction tests), and alsosignificantly potentiated phenobarbitone sodium–induced sleeping time. The results suggest thatMECB and MEBR exhibit CNS depressant activity in tested animal models.


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