The ethanolic extract of Fleurya interrupta Gaud. (Urticaceae) was tested for its possibleneuropharmacological effects on experimental animals. For the primary neuropharmacologicalscreening of this plant, the ethanolic extract of its aerial parts was subjected to preliminaryevaluation for acute toxicity, antinociceptive activity and central nervous system (CNS) activities.At the doses of 125 and 250 mg/kg, the extract significantly (P < 0.01 and P < 0.001) and dose-dependently increased the frequency of acetic acid induced writhing in mice. In thepentobarbitone induced sleeping time test, the extract at the above dose levels, significantly anddose-dependently decreased the pentobarbitone induced sleeping time (P < 0.001) and increasedthe time for onset of sleep (P < 0.001) in mice. In the open field and hole cross tests, test animalsshowed an increase in their movement in the both tests from the 2nd observation period (30 min)and persisted throughout the entire experimental period (240 min). These results of the extractmay attribute a stimulating action on the CNS. On the basis of these findings, it can be assumedthat the extract exerts its stimulating effect on the CNS in mice by interfering with the corticalfunction or increasing the effect of some CNS stimulating neurotransmitters.