The hot water extract of the seeds of Vernonia anthelmintica Kuntze (Compositae) in a dose of 10ml/kg body weight of mice, showed significant analgesic activity on the hot plate analgesicmethod throughout the 4 h experimental period. The hole cross scores and the climbing out scoresare of lower than the control animals. The hot water extract reduced the defecation in hole boardstudy and significantly reduces the exploratory ambulation and head dipping behaviour. The seedalso showed significant depressant activity on the exploratory ambulation of the open field scores.The drug decreased the spontaneous locomotion activity on brick-chip displacement method up to45 min and also showed the ability to lessen the amphetamine induced hyperactivity up to 20 min.But it didn’t show any effect on pentobarbital induced sleeping time test. The extract reducedgastrointestinal motility.