Anti-inflammatory effect of Samultang in human mast cell line HMC-1 > Volume 06 - 2006

본문 바로가기

사이트 내 전체검색


 » New Articles(2011~Present)
 » Articles (2001~2010)
      ∙ Volume 10 - 2010
      ∙ Volume 09 - 2009
      ∙ Volume 08 - 2008
      ∙ Volume 07 - 2007
      ∙ Volume 06 - 2006
      ∙ Volume 05 - 2005
      ∙ Volume 04 - 2004
      ∙ Volume 03 - 2003
      ∙ Volume 02 - 2002
      ∙ Volume 01 - 2001
 

Oriental Pharmacy and Experimental Medicine
Volume 06 - 2006
Date: 2006

Journal: Pages 237-244

September 2006 | Anti-inflammatory effect of Samultang in human mast cell line HMC-1…

In-Young Choi1, 2, Su-Jin Kim1,2, Tae-Hee Kang1, Byung-Hee Lee1, Joon-Ho Lee1, Ju-Young Lee1, Hyung-Min Kim2, Seung-Heon Hong1 and Jae-Young Um2,*

첨부파일

Summary

​Samultang has been believed for prevention and remedy various blood diseases such asmenstrual irregularity, anemia, and metrorrhagia. However, the mechanism that accounts foranti-inflammatory effects of the Samultang is still not fully understood. This study was designedto evaluate whether and how the Samultang could modulate the production of pro-inflammatorycytokines in phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 treated-human mast cell line, HMC-1. Samultang inhibited the production of tumor necrosis factor(TNF)-α, interleukin (IL)-6, granulocyte macrophage colony stimulating factor (GM-CSF), andvascular endothelial growth factor (VEGF) in HMC-1. Maximal inhibition rate of TNF-α, IL-6, GM-CSF,and VEGF by 0.1 mg/ml Samultang was about 70.73 ± 3.0%, 51.49 ± 4.14%, 54.03 ± 2.09%, and47.95±7.86%, respectively. Samultang partially blocked PMA plus A23187-induced cyclooxygenase(COX)-2 expression. In addition, Samultang inhibited activation of nuclear factor (NF)-κB, andextracellular signal-regulated kinase (ERK) activation. These results suggest that anti-inflammatoryeffect of Samulatng may be mediated by the suppression of cytokine production and COX-2activation via down-regulation of NF-κB and ERK activation.


This website Copyright (c) 2014 Institute of Korean Medicine Kyung Hee University All rights reserved.
Top View
Mobile View