Assessment of antibacterial activity of the cardiovascular drug nifedipine > Volume 06 - 2006

본문 바로가기

사이트 내 전체검색


 » New Articles(2011~Present)
 » Articles (2001~2010)
      ∙ Volume 10 - 2010
      ∙ Volume 09 - 2009
      ∙ Volume 08 - 2008
      ∙ Volume 07 - 2007
      ∙ Volume 06 - 2006
      ∙ Volume 05 - 2005
      ∙ Volume 04 - 2004
      ∙ Volume 03 - 2003
      ∙ Volume 02 - 2002
      ∙ Volume 01 - 2001
 

Oriental Pharmacy and Experimental Medicine
Volume 06 - 2006
Date: 2006

Journal: Pages 126-133

June 2006 | Assessment of antibacterial activity of the cardiovascular drug nifedipine…

Tapas Pal1, Noton Kumar Dutta2, Kaushiki Mazumdar2, Asish Dasgupta1, Jeyaseeli L1 and Sujata GDastidar1,*

첨부파일

Summary

​The cardiovascular drug nifedipine exhibited significant in vitro and in vivo antibacterialactivity against 331 strains of bacteria belonging to three Gram-positive and twelve Gram-negative genera. The minimum inhibitory concentration of the drug, as determined both byagar and broth dilution methods, was seen to range from 25 - 200 µg/ml against most testbacteria, including several pathogenic ones, in the in vitro studies. Nifedipine was bacteriostaticin action. In vivo studies with this drug showed that it could offer statistically significantprotection (P < 0.001) to mice challenged with a virulent bacterium. Therefore, nifedipine hasthe potential of an antibacterial agent, which may be developed after further pharmacologicalstudies.


This website Copyright (c) 2014 Institute of Korean Medicine Kyung Hee University All rights reserved.
Top View
Mobile View