Anxiolytic effect of chronic ginger treatment using elevated T- maze in mice > Volume 06 - 2006

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Oriental Pharmacy and Experimental Medicine
Volume 06 - 2006
Date: 2006

Journal: Pages 179-185

September 2006 | Anxiolytic effect of chronic ginger treatment using elevated T- maze in mice…

M Mohan1,*, SB Kasture2 and R Balaraman3

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Summary

​We investigated the effects of chronic administration of different extracts of ginger rhizome [petether extract (PE); toluene fraction (TF) of pet ether extract] on anxiety models: the elevated T- maze(ETM) (for inhibitory avoidance and escape measurements) and the open field test. Ondansetron(1 mg/kg), PE (10, 30 &100 mg/kg) and TF (10 & 30 mg/kg) were administered orally for 15 days.On the 14th day mice were previously exposed for 30 min to one of the open arms of the T-maze,24 h before the test. On 15th day mice had two exposures to the enclosed and open arm of the ETMfollowed by exposure to the open field apparatus. The number of line crossings in the apparatuswas used to assess locomotor changes. Cumulative Concentration Response Curve of 5-HT wasplotted using rat fundus which were pre-treated in a similar way. Treatment with Ondansetron(1 mg/kg), PE (100 mg/kg), TF (10 mg/kg) and TF (30 mg/kg) significantly (P < 0.05) impairedinhibitory avoidance performance but did not impair escape latency. Concentration responsecurve of 5-HT was shifted towards the right with suppression of maxima in rats treated with PEand TF. The results suggest that PE and TF of Ginger rhizome exerts anxiolytic like behaviour in aspecific subset of defensive behaviour, particularly those related to generalized anxiety disorder.


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