We examined the radioprotection effects of acupoint (acupuncture point) stimulation duringorganogenesis stages of ICR mice. Pregnant mice received 1.5 Gy whole body X-irradiation onday 8 of gestation, which is the early stage of organogenesis. The embryonic death rate andteratogenesis rate by radiation were examined. Electroacupuncture to the leg acupoints and/ortranscutaneous stimulation to the back acupoints on the pregnant mice showed no protectiveeffect against irradiation on embryonic or fetal death rate. On the contrary, the strong stimulationresulted in increase in the mortality after irradiation rather than protection. However acupointstimulation to the pregnant mice never showed harmful effects by itself on embryos. It tended toreduce the skeletal malformations induced by X-ray irradiation. We suspect that acupointstimulation removed the cells injured by irradiation during embryonic development, resulting inan increase in embryonic death rate and reduction in skeletal anomalies.