Analgesic and antipyretic actions of Muntingia calabura leaves chloroformextract in animal models > Volume 07 - 2007

본문 바로가기

사이트 내 전체검색


 » New Articles(2011~Present)
 » Articles (2001~2010)
      ∙ Volume 10 - 2010
      ∙ Volume 09 - 2009
      ∙ Volume 08 - 2008
      ∙ Volume 07 - 2007
      ∙ Volume 06 - 2006
      ∙ Volume 05 - 2005
      ∙ Volume 04 - 2004
      ∙ Volume 03 - 2003
      ∙ Volume 02 - 2002
      ∙ Volume 01 - 2001
 

Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2007

Journal: Pages 34-40

March 2007 | Analgesic and antipyretic actions of Muntingia calabura leaves chloroformextract in animal models…

ZA Zakaria1,*, G Hanan Kumar1, Siti NH Mohd Zaid1, Marwiza A Ghani 1, MH Hassan1, Nurul AMNHazalin1, Mahirah M Khamis1, G Rathna Devi1 and MR Sulaiman2

첨부파일

Summary

​The present study was carried out to elucidate the potential of Muntingia (M.) calabura leaveschloroform extract (MCCE) as antinociceptive, anti-inflammatory and antipyretic agents usingvarious animal models. The dried powdered leaves of M. calabura (20 g) were soaked in chloroformfor 72 h and the supernatant obtained was then evaporated to dryness. The crude dried extract (0.912g), dissolved in dimethyl sulfoxide (1:20; w/v) and considered as a stock solution (100%concentration/strength), was then diluted to the concentrations of 10 and 50% and used together in allexperimental models. The MCCE was found to show significant (P < 0.05) antinociceptive andantipyretic activities, but less remarkable anti-inflammatory activity. Only the antinociceptive activityof MCCE measured using the abdominal constriction test and in the first phase of the formalin testoccurred in a concentration-dependent manner. The anti-inflammatory activity of 50 and 100%concentrations MCCE was observed only at the range of time interval of 60 - 120 and 60 min,respectively. Based on the results, we conclude that the M. calabura leaves chloroform extractpossessed remarkable antinociceptive and antipyretic, but less effective anti-inflammatory, activitiesand thus justifies the Peruvian folklore claims of its medicinal values.


This website Copyright (c) 2014 Institute of Korean Medicine Kyung Hee University All rights reserved.
Top View
Mobile View