The roots of the plant Korean ginseng have been extensively used in the traditional Chineseherbal medicine. The effects of chronic administration of Korean ginseng extract (KGE) wereinvestigated on two different anxiety models: the elevated T-maze (for inhibitory avoidance andescape measurements) and the open field test (OFT). Diazepam (1 mg/kg), KGE (10, 30 and 100mg/kg) were administered orally for 15 days. On the 14th day, mice were previously exposed for30 min to one of the open arms of the T-maze, 24 h before the test. On 15th day, mice had twoexposures to the enclosed and open arm of the elevated T-maze followed by exposure to the openfield apparatus. The number of line crossings in the apparatus was used to assess locomotorchanges. Cumulative Concentration Response Curve of 5-HT was plotted using rat fundus whichwere pre-treated in a similar way. Treatment with Diazepam (1 mg/kg) and KGE (10, 30 and 100mg/kg) significantly (P<0.05) impaired inhibitory avoidance performance but did not impairescape latency. In OFT, diazepam facilitated locomotion as compared to vehicle and othertreatment groups. KGE at any of the selected doses did not impair locomotion. Concentrationresponse curve of 5-HT was shifted towards the right with suppression of maxima in rats treatedwith KGE. The results suggest that KGE exerts anxiolytic like behaviour in a specific subset ofdefensive behaviour, particularly those related to generalized anxiety disorder.