Hepatoprotective activity of methanol extracts of Glinus oppositifolius andTrianthema decandra against paracetamol induced liver damage > Volume 07 - 2007

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Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2007

Journal: Pages 74-78

March 2007 | Hepatoprotective activity of methanol extracts of Glinus oppositifolius andTrianthema decandra against paracetamol induced liver damage…

M Gupta1, UK Mazumder1, CC Kandar2,*, PK Haldar2, L Manikandan1 and GP Senthilkumar1

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Summary

​The plants, Trianthema decandra and Glinus oppositifolius are commonly used by tribal people inIndia for the treatment of liver diseases. Hepatoprotective activity of methanol extracts of Glinusoppositifolius and Trianthema decandra at the dose of 250 and 500 mg/kg body weight administeredorally was evaluated against paracetamol induced liver damage in rats. Biochemical parameterssuch as serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase,serum alkaline phosphatase, bilirubin, total serum protein, lipid peroxide and glutathione contentof the liver were estimated to determine liver function and metabolism. From the biochemicalobservations, it was concluded that methanol extracts of Glinus oppositifolius and Trianthemadecandra significantly restored the altered biochemical parameters towards normal condition inparacetamol induced liver damage.


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