Anti-inflammatory, anti-ulcer and hypoglycaemic activities of ethanolic andcrude alkaloid extracts of Madhuca indica (Koenig) Gmelin seed cake > Volume 07 - 2007

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Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2007

Journal: Pages 141-149

March 2007 | Anti-inflammatory, anti-ulcer and hypoglycaemic activities of ethanolic andcrude alkaloid extracts of Madhuca indica (Koenig) Gmelin seed cake…

Seshagiri M1, Gaikwad RD1, Paramjyothi S1,*, Jyothi KS2 and Ramchandra S3

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Summary

​Madhuca indica has been used ethnomedically in Indian folks. In the present study we haveinvestigated anti-inflammatory, anti-ulcer and hypoglycaemic effect of ethanolic extract (EE) andcrude alkaloid extract of Madhuca indica seed cake on albino rats. The study showed that the EEhad a significant, dose dependent anti-edematogenic, anti-ulcerogenic and hypoglycaemic activity,whereas the crude alkaloid extract exhibited a significant anti-inflammatory activity only. Both theextracts possess dose dependent inhibitory activity on carrageenan-induced edema, inhibitingprostaglandins or mediators involved in prostaglandin synthesis, the second phase of inflammation. TheEE was significantly effective in protecting pylorus-ligation-induced gastric ulcers at a higher dose level.The active principle of EE seems to be a selective inhibitor of the COX II (prostaglandin synthesis)without important effect on COX I since, EE exhibited both anti-edematogenic and anti-ulcerogeniceffect. The EE was effective in reducing the plasma glucose level in normal albino rats in a dosedependent manner, producing hypoglycaemic effect by stimulating the release of insulin from the β-cellsand/or increasing the uptake of glucose from the plasma.


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